Researchers have discovered the pain-relieving possibility of cannabis (CBD) for years, but they have had to look forward until now to determine how the plant produces such effective substances. Their findings may help give a solution to the opioid trial.
People can remedy chronic pain using various different medications. However, specialists commonly prescribe opioids for pain that is fixed. Opioids work by joining themselves to nerve cell receptors in many parts of the body, obstructing pain signals that are moving to the brain. Although powerful, the dark side of opioids is the risk of addiction — especially when a patient takes them for a long period. More than 130 patient in the United States dies of an opioid overdose every day, according to the National Institute on Drug Abuse (NIDA). The issue is so severe that officials have identified it as a public health crisis.
“There’s definitely a need to extend alternatives for relief of chronic and acute pain that go beyond opioids,” says Professor Tariq Akhtar, from the administration of molecular and cellular biology at the University of Guelph (Ontario, Canada).
According to Professor T.Akhtar and other researchers at the university, cannabidiol (CBD) could be the solution.
Typical pain relievers
In the 1980s, scientists classified 2 cannabis molecules: cannflavin A and B. “These molecules are nonpsychoactive, and they target the inflammation at the source, making them ideal painkillers,” explains Prof. Akhtar. In fact, Scientists found that flavonoids, as the molecules are now identified, are approximately 30 times better at decreasing inflammation than aspirin. But, due to administrative laws, Scientists made limited progress in figuring out how the cannabis plant produces flavonoids. Unto now, that is.
Cannabidiol (CBD) use has now become normalized and even legal in some states, including Canada. The University of Guelph team worked this change of situation to delve into the molecule-making method.”Our goal was to better understand how this Cannabidiol (CBD) is made, which is a relatively straightforward exercise these days,” says Professor T. Akhtar.”There are multiple sequenced genomes that are publicly ready, including the genome of Cannabis sativa, which can be worked for information. If you know what you’re searching for, one can bring genes to life, so to speak, and piece together how molecules like cannflavin A and cannflavin B are assembled.”
Creating more important batches.
Using biochemistry processes, the Researchers was able to determine the plant genes necessary to assemble the 2 molecules. They also knew the specific steps that occurred in flavonoid production, publishing them in Phytochemistry.
However, this study alone is not enough to create a brand-new natural pain reliever. “The difficulty with these molecules is they are present in cannabis at such low levels, it’s not possible to try to engineer the cannabis plant to produce more of specific components,”
Consequently, the team is teaming up with cannabis company Anahit International Corp. in the dream of finding a method to “engineer large quantities” of flavonoids.
“Company Anahit looking for to operating closely with University of Guelph team to produce effective & safe anti-inflammatory remedies from the cannabis plant that would give an option to nonsteroidal anti-inflammatory cures,” says Anahit’s major operating officer Darren Carrigan. Finally, the company plans to get this treatment available via a range of medical and athletic products, including pills, sports drinks, creams, and transdermal patches. In itself, this will be an accomplishment. But, if the partnership is flourishing, the best part is that the pain cure will come without an addiction risk.”Being able to offer a new pain relief choice is exciting, and we are proud that our job has the potential to become a new tool in the pain remedy arsenal.”